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BHC Collaborates on NIH Funded Study to Identify ME/CFS Antibody Biomarkers

A $200,000 grant from National Institute of Allergy and Infectious Diseases has been awarded for a study seeking to identify antibody biomarkers for ME/CFS. The Bateman Horne Center will partner with Armin Alaedini, PhD on this important research.

Suzanne D VernonBy Suzanne D Vernon

We know ME/CFS is a very heterogeneous condition with different causes and different constellation of symptoms.  There is evidence for a least six ME/CFS subtypes and it would be important to identify and treat these various subtypes accordingly.  Biomarkers can be used to identify ME/CFS Seeking Antibody Biomarkersbiomarker subtypes and a promising biomarker is antibodies. Antibodies are proteins that our body’s immune system produces in response to things like viruses or bacteria. We also know that our immune system can produce antibodies against parts of our own cells and tissues, a potentially harmful response called autoimmunity. Our body can also produce antibodies to food proteins like wheat gluten. Antibody biomarkers could be used to delineate a viral ME/CFS subtype from an autoimmune ME/CFS subtype from gastrointestinal ME/CFS subtype.

 

Armin Alaedini, PhD eeking to Identify Antibody Biomarkers for ME/CFS

Armin Alaedini, PhD

A few years ago I started working with Armin Alaedini, PhD from Columbia University to determine if there were antibodies being produced against central nervous system proteins in ME/CFS patients but did not find any. Because some ME/CFS patients have “gut issues”, Alaedini examined whether there was a distinct intestinal immune response in ME/CFS.  Indeed, his preliminary data demonstrated that in a subgroup of ME/CFS patients with gastrointestinal symptoms there were more antibodies to wheat gluten (this manuscript is in preparation).

Using this preliminary data, Dr. Alaedini proposed a study to further characterize the intestinal immune response in ME/CFS and examine whether it could be associated with bacteria moving across the gut and instigating inflammation.  He submitted his application in January 2015 for the NIH ME/CFS funding opportunity (http://grants.nih.gov/grants/guide/pa-files/PAR-12-033.html) and just received word that he was awarded $200,000 from National Institute of Allergy and Infectious Diseases for this grant!

Read the study abstract, here: https://goo.gl/yPc6e3.

For too long, research in ME/CFS has been lean and under-funded for several reasons, including the shortage of accurately diagnosed patients available for research studies.  The Bateman Horne Center – a clinic specializing in ME/CFS/FM and with a large number of patients who have been carefully and accurately diagnosed, and continue to be treated effectively – will partner with Dr. Alaedini to provide additional well-characterized samples from ME/CFS patients and controls.  In addition, we connected Dr. Alaedini with Drs. Sanjay Shukla and Dane Cook.  Alaedini will be testing the blood samples Shukla’s team (https://goo.gl/JLdmMa) collected before and after exercise to examine the intestinal immune response and antibodies as biomarkers of post-exertional malaise.

The Bateman Horne Center is committed to bringing ME/CFS and FM into the mainstream of clinical and medical science. Identifying biomarkers is a critical first step. The Bateman Horne Center is a unique example of an independent non-profit integrative health center where medical care informs research, and research informs medical care. We are uniquely positioned to create collaborations between amazing, well-qualified patients and stellar research partners – an important component to progress.

We’ve got a big job to do and we need more patients and researchers involved in research to make objective diagnosis and treatment a reality for all impacted by ME/CFS and Fibromyalgia.  Until that day, all “wild sock wearing” feet on deck!

Together we can!

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Donate Now!Everything we accomplish is dependent on the support from others.  We have two immediate goals – to train new clinician research staff and to move to a larger, more suitable building. Both of these goals, when achieved, dramatically increase our ability to see more patients and implement higher quality research. We also dream of hiring a new physician right out of residency, building them up into a life-long career of compassionate, comprehensive ME/CFS and FM care.

YOU can help us achieve these goals. We need to raise $300,000 this Spring. A lofty goal, yet when we gather together, work in cooperation, with great integrity and care, we can change the world for all those impacted by ME/CFS and FM. DONATE TODAY

 

6 Comments

  1. Jessica Lewis on March 2, 2016 at 7:30 pm

    As a patient, I will share this info. with as many potential donors as possible. I would love to participate in this biomarker research study as it becomes available. Eternal thanks to all of you in your tireless research to help those of us suffering each day.



    • Blog Admin on March 3, 2016 at 11:09 am

      Thank you Jessica! BHC is incredibly efficient with the dollars it receives, but we desperately need more funding to continue and expand our important work. Your help in this regard is deeply appreciated.



  2. Lisa Marshall on March 3, 2016 at 5:09 pm

    I would be interested in participating in the research. How would someone become involved in this research?



  3. Ann McKenna on March 5, 2016 at 3:14 am

    I am very excited to hear this info and would love to be involved in this study. Great news for those of us with CFS. Thank-you, thank-you, thank-you.



  4. Bradley Baker on March 12, 2016 at 1:16 pm

    I support you with all of my heart and all of my soul. Unfortunately after 23 yrs, what I’m most short of is energy to be involved and help that way and money of which I have little, but some….. I’ll be sending donations (however lg or sm) soon. God bless you. Sincerely, Brad Baker



    • Blog Admin on March 14, 2016 at 12:42 pm

      Brad, some give from their surplus and others from their need; each gift is a blessing we endeavor to honor. We are humbled and blessed by your trust in us. Every single penny we receive is valued, appreciated, and understood not to be ours, but to belong to all those suffering with ME/CFS and FM. We work hard to ensure we are investing it as wisely as possible to ensure the greatest return. We understand how important the work is and that patients are waiting. May we always be worthy of the trust you place in us.