Assessment & Management of PASC
Many of the following resources reflect guidance on how to approach the assessment and care management of ME/CFS, which will assist in supporting patients with other post-viral syndromes such as long-COVID.
- CDC Interim Guidance: Evaluating & Caring for Patients with Post-COVID Conditions
- AAPM&R: Long COVID (PASC) Guidance
- AAPM&R: Assessment & Treatment of Fatigue in PASC
- AAPM&R: Assessment and treatment of cardiovascular complications in PASC
- AAPM&R: Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of postacute sequelae of SARS-CoV-2 infection (PASC) in children and adolescents
Learning from other post-viral syndromes
- Mayo Clinic Proceedings: ME/CFS: Essentials of Diagnosis and Management
- US ME/CFS Clinician Coalition: Testing Recommendations for Suspected ME/CFS
- US ME/CFS Clinician Coalition: ME/CFS Treatment Recommendations
- BHC: Assessing & Managing Aspects of ME/CFS
- Frontiers: Will COVID-19 Lead to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
- Doctors With M.E. Putting it into Practice: What NICE ME/CFS means for GPs
- Post COVID-19 Fatigue, Post/Long COVID-19 Syndromes & Post-COVID ME/CFS
- Caring for People with Severe ME/CFS (letter to providers)
- Healthcare: Caring for the Patient with Severe or Very Severe Myalgic/Encephalomyelitis/Chronic Fatigue Syndrome
Criteria-Specific Guidance
- Orthostatic Intolerance (basics, symptoms, interventions)
- Assessing Orthostatic Intolerance: 10-Minute NASA Lean Test (provider instructions)
- Mast cell activation syndrome (MCAS): video, slides
- Post-Exertional Malaise (PEM)
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- Teach Pacing!!
- ME/CFS Crash Survial Guidebook
- Workwell Foundation: PEM Patient Handout
- Frontiers in Neurology: Characterization of post-exertional malaise in patients with ME/CFS
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Short Videos

- Clinical Presentation of Long COVID Subset Similar to ME/CFS (16 min)
- What is ME/CFS? (diagnostic criteria- 6 min)
- What is Orthostatic Intolerance in ME/CFS Part 1 (assessment- 6 min)
- What is Orthostatic Intolerance in ME/CFS Part 2 (management -5 min)
- Addressing Orthostatic Intolerance in ME/CFS (13 min)