On this page, BHC provides resources from CME offerings and other professional literature specific to these diseases.


ME/CFS Diagnostic Criteria
Symptoms Supporting Diagnosis
Diagnosing and Managing ME/CFS
Top Resources


Functional Impairment
Post-Exertional Malaise
Unrefreshing Sleep
Cognitive Impairment
Orthostatic Intolerance

Project ECHO

Long COVID & Post-Viral Syndrome


Severe ME/CFS

Post-Exertional Malaise/Post-Exertional Symptom Exacerbation (PEM/PESE)

This seven-part video series is a comprehensive deep-dive into (PEM/PESE).

It is critical that healthcare professionals recognize PEM/PESE and support the patient in avoiding a push-crash-cycle which can exacerbate disease processes and contribute to worsened long-term functional prognoses.

This lecture series will equip providers with information on the pathophysiology of PEM/PESE, common triggers, and offer care and management guidance.

Continuing Medical Education for Healthcare Professionals

Research and Evidence-based Literature

Mayo Clinic Proceedings 

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Managment
Author: Lucinda Bateman, MD, US ME/CFS Clinician Coalition 

Editorial: Advances in ME/CFS Research and Clinical Care

Kenneth J. Friedman, Lucinda Bateman, Alison Bested and Zaher Nahle
Published:  on 18 September 2019
Front. Pediatr. doi: 10.3389/fped.2019.00370

Initiating Care of a Patient With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

Charles W. Lapp
Perspective: This paper introduces the primary care physician to the unique and challenging aspects of initially diagnosing and managing a complex condition for which there are a plethora of symptoms, few physical findings, no known cause…
Published: on 23 January 2019
Front. Pediatr. doi: 10.3389/fped.2018.00415

Onset Patterns and Course of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Lily Chu,  Ian J. Valencia, Donn W. Garvert and Jose G. Montoya
Original Research Background: Epidemiologic studies of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) have examined different aspects of this disease separately but few have explored them together. Objective: Describe ME/CFS onset and course in one United …
Published: on 05 February 2019
Front. Pediatr. doi: 10.3389/fped.2019.00012

Estimating Prevalence, Demographics, and Costs of ME/CFS Using Large Scale Medical Claims Data and Machine Learning

Ashley R. Valdez, Elizabeth E. Hancock, Seyi Adebayo, David J. Kiernicki, Daniel Proskauer, John R. Attewell, Lucinda Bateman, Alfred DeMaria, Charles W. Lapp, Peter C. Rowe and Charmian Proskauer
Original Research: Techniques of data mining and machine learning were applied to a large database of medical and facility claims from commercially insured patients to determine the prevalence, gender demographics, and costs for individuals with provider-assigned …
Published: on 08 January 2019
Front. Pediatr. doi: 10.3389/fped.2018.00412

Orthostatic Intolerance Syndromes

Cardiopulmonary Exercise Test Methodology for Assessing Exertion Intolerance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Staci Stevens, Chris Snell, Jared Stevens, Betsy Keller and J. Mark VanNess
Methods Background: Concise methodological directions for administration of serial cardiopulmonary exercise testing (CPET) are needed for testing of patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Maximal CPET is used to evaluate …
Published: on 04 September 2018
Front. Pediatr. doi: 10.3389/fped.2018.00242

Low Sensitivity of Abbreviated Tilt Table Testing for Diagnosing Postural Tachycardia Syndrome in Adults With ME/CFS

C. (Linda) M. C. van Campen, Peter C. Rowe and Frans C. Visser
Original Research Introduction: Orthostatic intolerance is common among individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In some ME/CFS case definitions, orthostatic intolerance is considered a core feature of the disorder. Some studies …
Published: on 16 November 2018
Front. Pediatr. doi: 10.3389/fped.2018.00349

Blood Volume Status in ME/CFS Correlates With the Presence or Absence of Orthostatic Symptoms: Preliminary Results

C. (Linda) M. C. van Campen, Peter C. Rowe and Frans C. Visser
Brief Research Report Introduction: Conflicting data have been published on the reduction of circulating blood volume in adults with Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The aim of the present study was to compare blood volumes based on the …
Published: on 15 November 2018
Front. Pediatr. doi: 10.3389/fped.2018.00352

Pediatric, Adolescents, and Youth with ME/CFS
School Functioning in Adolescents With Chronic Fatigue Syndrome

Sarah Jenette Knight , Jennifer Politis, Christine Garnham, Adam Scheinberg and Michelle Anne Tollit
Original Research Background: It is well known that adolescents with chronic fatigue syndrome (CFS) experience greater school absenteeism compared to healthy adolescents. Less is known about other important aspects of school functioning including school participation, …
Published: on 16 October 2018
Front. Pediatr. doi: 10.3389/fped.2018.00302

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer

Peter C. Rowe, Rosemary A. Underhill, Kenneth J. Friedman, et. al
Published: on 19 June 2017
Front. Pediatr. doi: 10.3389/fped.2017.00121

Meeting the Educational Needs of Young, ME/CFS Patients: Role of the Treating Physician

Faith R. Newton
Published: on 02 April 2019
Front. Pediatr. doi: 10.3389/fped.2019.00104

The Importance of Accurate Diagnosis of ME/CFS in Children and Adolescents: A Commentary

Keith James Geraghty and Charles Adeniji
Perspective: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic illness that causes a range of debilitating symptoms. While most research has focused on adults, the illness also presents in children and adolescents. Many physicians find it …
Published: on 21 January 2019
Front. Pediatr. doi: 10.3389/fped.2018.0043

Long Term Follow up of Young People With Chronic Fatigue Syndrome Attending a Pediatric Outpatient Service

Katherine S. Rowe
Original Research Aim: To determine the reported duration of illness, the functional and educational long-term outcomes, predictive factors for recovery and seek feedback regarding management in pediatric/adolescent myalgic encepahalomyelitis/chronic fatigue syndrome …
Published: on 21 February 2019
Front. Pediatr. doi: 10.3389/fped.2019.00021

Impaired Health-Related Quality of Life in Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Impact of Core Symptoms

Maria Roma, Colleen L. Marden , Marissa A. K. Flaherty, Samantha E. Jasion, Erica M. Cranston and Peter C. Rowe
Original Research Objective: The objectives of this study were to compare the health-related quality of life (HRQOL) of a North American population of adolescents and young adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) to (1) healthy controls …
Published: on 15 February 2019
Front. Pediatr. doi: 10.3389/fped.2019.00026

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